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CHINA- INTERACCIÓN ENTRE EL HUÉSPEDE Y EL PARÁSITO Y LA DEPURACIÓN DE LA SELECCIÓN DE UN PARÁSITO MICROSPORIDIO EN LAS ABEJAS MELLIFERAS

Miércoles 10 de Febrero de 2016 16:38 por Analia Manriquez
Documento elaborado por  Qiang Huang , Yan Ping Chen, Rui Wu Wang , Shang Cheng y  Jay D. Evans. Por favor descargue el documento adjunto

Abstract

To clarify the mechanisms of Nosema ceranae parasitism, we deep-sequenced both honey bee host and parasite mRNAs throughout a complete 6-day infection cycle. By time-series analysis, 1122 parasite genes were significantly differently expressed during the reproduction cycle, clustering into 4 expression patterns. We found reactive mitochondrial oxygen species modulator 1 of the host to be significantly down regulated during the entire infection period. Our data support the hypothesis that apoptosis of honey bee cells was suppressed during infection. We further analyzed genome-wide genetic diversity of this parasite by comparing samples collected from the same site in 2007 and 2013. The number of SNP positions per gene and the proportion of non-synonymous substitutions per gene were significantly reduced over this time period, suggesting purifying selection on the parasite genome and supporting the hypothesis that a subset of N. ceranae strains might be dominating infection.

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