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EE.UU.- LA EXPOSICIÓN A LOS ANTIBIÓTICOS PERTURBA LA MICROBIOTA DEL INTESTINO Y ELEVA LA MORTALIDAD EN LAS ABEJAS

Miércoles 19 de Abril de 2017 14:37 por Analia Manriquez

Documento elaborado por  Kasie Raymann ,  Zack Shaffer y Nancy A. Moran. Por favor descargue el documento adjunto

 

 

Abstract

 

Gut microbiomes play crucial roles in animal health, and shifts in the gut microbial community structure can have detrimental impacts on hosts. Studies with vertebrate models and human subjects suggest that antibiotic treatments greatly perturb the native gut community, thereby facilitating proliferation of pathogens. In fact, persistent infections following antibiotic treatment are a major medical issue. In apiculture, antibiotics are frequently used to prevent bacterial infections of larval bees, but the impact of antibiotic-induced dysbiosis (microbial imbalance) on bee health and susceptibility to disease has not been fully elucidated. Here, we evaluated the effects of antibiotic exposure on the size and composition of honeybee gut communities. We monitored the survivorship of bees following antibiotic treatment in order to determine if dysbiosis of the gut microbiome impacts honeybee health, and we performed experiments to determine whether antibiotic exposure increases susceptibility to infection by opportunistic pathogens. Our results show that antibiotic treatment can have persistent effects on both the size and composition of the honeybee gut microbiome. Antibiotic exposure resulted in decreased survivorship, both in the hive and in laboratory experiments in which bees were exposed to opportunistic bacterial pathogens. Together, these results suggest that dysbiosis resulting from antibiotic exposure affects bee health, in part due to increased susceptibility to ubiquitous opportunistic pathogens. Not only do our results highlight the importance of the gut microbiome in honeybee health, but they also provide insights into how antibiotic treatment affects microbial communities and host health.

Author summary

There is growing evidence for the importance of gut microbes in animal health. Unlike most other insects, honeybees possess a highly conserved gut microbial community, which is acquired through social contact, and several results have suggested that these microbes play an important role in honeybee health. Antibiotics, which can severely disrupt gut microbial communities, are commonly used in beekeeping in several countries. However, it is unknown how antibiotic treatment affects the gut microbial communities of honeybees. Here, we evaluated the effects of antibiotic treatment on the size and composition of the honeybee gut microbiome and on honeybee health. We found that exposure to antibiotics significantly alters the honeybee gut microbial community structure and leads to decreased survivorship of honeybees in the hive, likely due to increased susceptibility to infection by opportunistic pathogens.

 

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